The 63rd Annual Conference of the Particle Therapy Cooperative Group (PTCOG 63) is scheduled for June 2–7, 2025, in Buenos Aires, Argentina. This landmark event marks PTCOG’s first conference in South America and coincides with the inauguration of Argentina’s first Proton Therapy Center (CeArP), a significant advancement in cancer treatment for the region. The conference will feature two days of educational sessions followed by three days of scientific presentations, workshops, and networking opportunities, all under the theme “Bridging Borders in Particle Therapy.